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#3
08-04-2005, 04:10 PM
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 Re: Inflammatory pulmonary diseases / iron-chelating therapy Taaa .. ber.. nach .. Fermez .. le .. grande .. bush .. Eh .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking |
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#2
08-04-2005, 07:33 AM
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| Re: Inflammatory pulmonary diseases / iron-chelating therapy mcs a écrit dans le message ... - quote - > I have taken anti oxidants all my life and no effect and still have asthma,
You are correct! People who push phoney treatments> However take me out of moderat or higher polluted cities and I am almost > better. There will be no cure EVER for people who has to breathe this toxin > in. Its like saying there will be a cancer free cigarette. > <ironjustice[at]aol.com> wrote in message > news:1122835831.239688.224860[at]z14g2000cwz.googlegroups.com... > Iron-binding drugs targeted to lysosomes: a potential strategy to treat > inflammatory lung disorders. > such as the so called "iron-chelating therapy" are among the worst of the low lifes on the planets. People who think humans are herbivores are among the stupidest on the planet!! |
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#1
08-04-2005, 02:55 AM
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| Re: Inflammatory pulmonary diseases / iron-chelating therapy - quote - > > In many inflammatory lung disorders, an abnormal assimilation of redox-active iron will exacerbate oxidative tissue damage (snip) << Oh God, another iron monger . . . (plonk = killfile drawer) Will, crna |
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08-04-2005, 02:32 AM
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| Re: Inflammatory pulmonary diseases / iron-chelating therapy I have taken anti oxidants all my life and no effect and still have asthma, However take me out of moderat or higher polluted cities and I am almost better. There will be no cure EVER for people who has to breathe this toxin in. Its like saying there will be a cancer free cigarette. <ironjustice[at]aol.com> wrote in message news:1122835831.239688.224860[at]z14g2000cwz.googlegroups.com... Iron-binding drugs targeted to lysosomes: a potential strategy to treat inflammatory lung disorders. Persson HL, Richardson DR Expert Opin Investig Drugs. 2005 Aug ; 14(8): 997-1008 In many inflammatory lung disorders, an abnormal assimilation of redox-active iron will exacerbate oxidative tissue damage. It may be that the most important cellular pool of redox-active iron exists within lysosomes, making these organelles vulnerable to oxidative stress. In experiments employing respiratory epithelial cells and macrophages, the chelation of intra-lysosomal iron efficiently prevented lysosomal rupture and the ensuing cell death induced by hydrogen peroxide, ionising radiation or silica particles. Furthermore, cell-permeable iron-binding agents (weak bases) that accumulate within lysosomes due to proton trapping were much more efficient for cytoprotection than the chelator, desferrioxamine. On a molar basis, the weak base alpha-lipoic acid plus was 5000 times more effective than desferrioxamine at preventing lysosomal rupture and apoptotic cell death in cell cultures exposed to hydrogen peroxide. Thus, iron-chelating therapy that targets the lysosome might be a future treatment strategy for inflammatory pulmonary diseases. Abstract · PubMed · FullText · SFX · LF+ · GS · Order · Clip · Citation · BibTeX · Related · TouchGraph · Scopus · References · Tag tags: annotation: Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking |
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#-1
07-31-2005, 06:50 PM
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| Inflammatory pulmonary diseases / iron-chelating therapy Iron-binding drugs targeted to lysosomes: a potential strategy to treat inflammatory lung disorders. Persson HL, Richardson DR Expert Opin Investig Drugs. 2005 Aug ; 14(8): 997-1008 In many inflammatory lung disorders, an abnormal assimilation of redox-active iron will exacerbate oxidative tissue damage. It may be that the most important cellular pool of redox-active iron exists within lysosomes, making these organelles vulnerable to oxidative stress. In experiments employing respiratory epithelial cells and macrophages, the chelation of intra-lysosomal iron efficiently prevented lysosomal rupture and the ensuing cell death induced by hydrogen peroxide, ionising radiation or silica particles. Furthermore, cell-permeable iron-binding agents (weak bases) that accumulate within lysosomes due to proton trapping were much more efficient for cytoprotection than the chelator, desferrioxamine. On a molar basis, the weak base alpha-lipoic acid plus was 5000 times more effective than desferrioxamine at preventing lysosomal rupture and apoptotic cell death in cell cultures exposed to hydrogen peroxide. Thus, iron-chelating therapy that targets the lysosome might be a future treatment strategy for inflammatory pulmonary diseases. Abstract · PubMed · FullText · SFX · LF+ · GS · Order · Clip · Citation · BibTeX · Related · TouchGraph · Scopus · References · Tag tags: annotation: Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking |
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| diseases, inflammatory, ironchelating, pulmonary, therapy |
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