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| I received an email from someone named Carol, which I just read. She requested the link to the experimental studies that found that there is no such thing as "EFAD," unless the animal can't synthesize the Mead acid, due to vitamin B6 deficiency. Note that they sometimes say arachidonic acid when they mean Mead acid, because Mead acid was not discovered until after these experiments, in 1952. QUOTE: ...In the studies with tri-di-deuterio-iso-olein mentioned under Section A above, the fatty acids from the carcasses and hides were analyzed spectrophotometrically and it was found that the arachidonic acid content of the carcass fat increased as the experiment period continued. Thus, it appears that arachidonic acid was synthesized by the rats. This conclusion was greatly strengthened [illegible] our finding that deuterium was present in the arachidonic acid molecule for it indicated that the arachidonic acid was synthesized from a deuteriumated iso-oleic acid in the diet. This evidence that the rat can synthesize an "essential" fatty acid is of considerable scientific interest... [when?] fed a pyridoxine-deficient diet, rats develop a scaliness of the paws and tails which is hardly distinguishable from the syndrome which develops from a deficiency in "essential" fatty acids. Others have demonstrated that pyridoxine is necessary for the formation of fat from protein. From this we have reasoned that there may be an interrelationship between pyridoxine and "essential" fatty acids. We have demonstrated that this deficiency condition can be cured by feeding pyridoxine but that it is not affected by feeding linoleic acid. The effects of pyridoxine have been confirmed in a repeat experiment. The evidence indicates that pyridoxine deficiency not only decreases the appetite of rats but also the efficiency of food utilization. It appears that rats store only small amounts of pyridoxine, for their growth rate was retarded within five days after they were placed on a pyridoxic-free ration. The rats fed no pyridoxine consumed nearly twice as much food per gram gain in weight as those fed pyridoxic in fat-free diets or in diets containing olive oil. More fat was deposited in their tissues when pyridoxine and/or fat, was present in the diet. The dermatitis which developed after two to four weeks on a fat-free pyridoxine-free diet was partially cured by feeding pyridoxine, and completely cured when both pyridoxine and linoleic acid were added. The percentage of arachidonic acid in the carcass fatty acids was lowest when olive oil and pyridoxine were present in the diet of the rats. The total amount of arachidonic acid was greatest in those rats fed pyridoxine in the diet. It is obvious that pyridoxine and arachidonic acid are interrelated in metabolism... The question arises whether the iso-oleic fatty acids were used in the synthesis of arachidonic acid. In an attempt to answer this question one group of rats, was given a fat-free synthetic diet; a (80-85 per cent normal oleic acid) added; and a third group was given this diet with 14 per cent elaidic acid (an iso-oleic acid) added. After 42 days the animals were destroyed, the fatty acids extracted from the carcasses and livers, and these acids analyzed for arachidonic acid content. The animals on the fat-free diet developed a very mild scaliness of the feet and tails. Since, in a later experiment, this condition was prevented by feeding additional amounts of the various vitamins in the supplement, it is considered possible that olive oil or elaidin in the diet exerts a vitamin-sparing action. The carcasses of the rats fed the fat-free diet contained definitely less fat, and the carcass fatty acids, were more saturated, than those from the rats fed olive oil or elaidic acid... Further, research may show that these differences in the arachidonic acid content of the carcass fats were due to differences in rate of utilization of this acid in metabolism... UNQUOTE. Source: http://www.gwu.edu/~nsarchiv/radiati...b_e/br4e1c.txt |
| Tags |
| carol, efa, original, request, studies |
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