ferrous[at]paris.com wrote:

- quote -

Would be nice if he cut his fingers off by shutting the cab door on them.
Then he could claim iron causes amputation.

It's bloody (pardon the pun) discouraging.
He always picks the same newsgroups to crosspost to.

If you look at alt.support.lupus, you and he are flooding this low activity
newsgroup with your crossposts.
http://groups.google.com/group/alt.support.lupus/about
This month
53 ironjustice[at]aol.com
24 ferr...[at]paris.com
22 teamtan...[at]hotmail.com
11 ironjustice
Almost half the posts are not support

Scares people away.
Some cannot filter threads or posters.
Discouraging...
Give it a break? Please, for a while.

"Nontransferrin bound iron in the pathogenesis of disease"

Am J Hematol. 2007 Oct 26; [Epub ahead of print]
Iron loading and its clinical implications.
Hershko C.
Shaare Zedek Medical Center, Jerusalem, Israel.


The main aspects of iron loading and the consequent clinical
implications described in this series of articles are summarized in
this final chapter. Despite mechanisms to maintain iron homeostasis,
harmful iron accumulation can occur in patients with hereditary
defects of regulatory proteins, such as hepcidin, or with
transfusion-
dependent anemias, such as thalassemia and myelodysplastic syndromes.
Identifying the role of nontransferrin bound iron in the pathogenesis
of disease allows for better treatment strategies to prevent and
reverse iron toxicity. In addition, accurate noninvasive methods to
reliably assess iron accumulation and chelation are now available.
Continuous chelation coverage, which can be achieved with combination
therapy (deferoxamine and deferiprone) or deferasirox, is expected to
provide optimal protection from iron toxicity. As more long-term data
on these drugs accumulate, the role of oral and combination chelation
therapies in relation to blood transfusion, as well as other iron
overload disorders, will become clearer. Am. J. Hematol., 2007. (c)
2007 Wiley-Liss, Inc.


PMID: 17963253 [PubMed - as supplied by publisher]


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

"diet restrictions may reduce mortality"

"Simple dietary restrictions may reduce the mortality risk associated
with high transferrin saturation"

Ann Fam Med. 2004 Mar-Apr;2(2):139-44. Related Articles, Links

The mortality risk of elevated serum transferrin saturation and
consumption of
dietary iron.


Mainous AG 3rd, Wells B, Carek PJ, Gill JM, Geesey ME.


Department of Family Medicine, Medical University of South Carolina,
Charleston, SC 29425, USA. maino...[at]musc.edu


BACKGROUND:
Recent data shows an increased mortality risk associated with
elevated transferrin saturation. Because ingestion of dietary iron
may
contribute to iron overload in persons with elevated transferrin
saturation, we
investigated the relationship between elevated transferrin
saturation,
ingestion of dietary iron and red meat, and mortality.
METHODS:
This 12-year
cohort study used data from the second National Health and Nutrition
Examination Survey 1976-1980 (NHANES II) and the NHANES II Mortality
Study
1992. Population estimates were based on 9,229 persons aged 35 to 70
years at
baseline. A Cox proportional hazards analysis was performed based on
levels of
transferrin saturation, intake of dietary iron, and intake of red
meat. The
analysis was conducted while controlling for demographics, severity of
illness,
body mass index, and smoking status.
RESULTS:
Unadjusted analyses indicated
that those who had a high transferrin saturation and reported high
dietary iron
or red meat consumption had an increased mortality risk. The adjusted
survival
analysis indicated that persons with elevated transferrin saturation
who
reported high dietary iron intake had a hazard ratio for death of 2.90
(95%
confidence interval [CI], 1.39-6.04) compared with those with normal
transferrin saturation levels and reported low dietary iron intake.
Persons who
had a high transferrin saturation and reported high red meat
consumption also
had an increased hazard ratio for death (2.26; 95% CI, 1.45-3.52)
compared with
those who had normal transferrin saturation and reported low red meat
consumption.
CONCLUSIONS:
Ingestion of large quantities of dietary iron and red
meat in persons with high transferrin saturation is associated with an
increase
in mortality. Simple dietary restrictions may reduce the mortality
risk
associated with high transferrin saturation.


PMID: 15083854 [PubMed - in process]


-------------------------------

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

"Ann Fam Med. 2004 Mar-Apr;2(2):139-44. Related Articles, Links"

So which is it, the two 2007 studies describing normal control of iron
levels or this dated study? You posted all three.

Bloody fingernail hanging time now.

"diet restrictions may reduce mortality"

"Simple dietary restrictions may reduce the mortality risk associated
with high transferrin saturation"

Ann Fam Med. 2004 Mar-Apr;2(2):139-44. Related Articles, Links

The mortality risk of elevated serum transferrin saturation and
consumption of
dietary iron.


Mainous AG 3rd, Wells B, Carek PJ, Gill JM, Geesey ME.


Department of Family Medicine, Medical University of South Carolina,
Charleston, SC 29425, USA. maino...[at]musc.edu


BACKGROUND:
Recent data shows an increased mortality risk associated with
elevated transferrin saturation. Because ingestion of dietary iron
may
contribute to iron overload in persons with elevated transferrin
saturation, we
investigated the relationship between elevated transferrin
saturation,
ingestion of dietary iron and red meat, and mortality.
METHODS:
This 12-year
cohort study used data from the second National Health and Nutrition
Examination Survey 1976-1980 (NHANES II) and the NHANES II Mortality
Study
1992. Population estimates were based on 9,229 persons aged 35 to 70
years at
baseline. A Cox proportional hazards analysis was performed based on
levels of
transferrin saturation, intake of dietary iron, and intake of red
meat. The
analysis was conducted while controlling for demographics, severity of
illness,
body mass index, and smoking status.
RESULTS:
Unadjusted analyses indicated
that those who had a high transferrin saturation and reported high
dietary iron
or red meat consumption had an increased mortality risk. The adjusted
survival
analysis indicated that persons with elevated transferrin saturation
who
reported high dietary iron intake had a hazard ratio for death of 2.90
(95%
confidence interval [CI], 1.39-6.04) compared with those with normal
transferrin saturation levels and reported low dietary iron intake.
Persons who
had a high transferrin saturation and reported high red meat
consumption also
had an increased hazard ratio for death (2.26; 95% CI, 1.45-3.52)
compared with
those who had normal transferrin saturation and reported low red meat
consumption.
CONCLUSIONS:
Ingestion of large quantities of dietary iron and red
meat in persons with high transferrin saturation is associated with an
increase
in mortality. Simple dietary restrictions may reduce the mortality
risk
associated with high transferrin saturation.


PMID: 15083854 [PubMed - in process]


-------------------------------

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Wow, another great post. This one also explains that iron overload
occurs because there is often a genetic or other disorder disrupting the
normal control of iron levels. Normally in most people this never
happens despite iron in the diet.

Another post that goes in the iron hall of shame which are those post
which by his own hand mr. justice refutes the iron causes all disease
because people eat meat notion.

"Despite mechanisms to maintain iron homeostasis, harmful iron
accumulation can occur in patients with hereditary defects of regulatory
proteins, such as hepcidin, or with transfusion- dependent anemias, such
as thalassemia and myelodysplastic syndromes."

"Nontransferrin bound iron in the pathogenesis of disease"

Am J Hematol. 2007 Oct 26; [Epub ahead of print]
Iron loading and its clinical implications.
Hershko C.
Shaare Zedek Medical Center, Jerusalem, Israel.

The main aspects of iron loading and the consequent clinical
implications described in this series of articles are summarized in
this final chapter. Despite mechanisms to maintain iron homeostasis,
harmful iron accumulation can occur in patients with hereditary
defects of regulatory proteins, such as hepcidin, or with transfusion-
dependent anemias, such as thalassemia and myelodysplastic syndromes.
Identifying the role of nontransferrin bound iron in the pathogenesis
of disease allows for better treatment strategies to prevent and
reverse iron toxicity. In addition, accurate noninvasive methods to
reliably assess iron accumulation and chelation are now available.
Continuous chelation coverage, which can be achieved with combination
therapy (deferoxamine and deferiprone) or deferasirox, is expected to
provide optimal protection from iron toxicity. As more long-term data
on these drugs accumulate, the role of oral and combination chelation
therapies in relation to blood transfusion, as well as other iron
overload disorders, will become clearer. Am. J. Hematol., 2007. (c)
2007 Wiley-Liss, Inc.

PMID: 17963253 [PubMed - as supplied by publisher]


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk