Sirtris Reports Promising Diabetes Study

#6 01-09-2008, 02:56 PM

On Jan 8, 6:26*pm, "Cubit" <n...[at]not.not> wrote:FYI: Mercola sells a
supplement called Radical Fruits that is supposed to have some
resveratrol in it. <<

A peanut butter and jelly sandwich .. on whole wheat .. bread ..

Resveratrol found in both peanut butter and jelly and phyate another
iron binder ..

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

- quote -

> "Marilyn Mann" <ma...[at]comcast.net> wrote in message
>
> news:569e9ad6-685d-4fef-a7e7-70efbbc5f959[at]v4g2000hsf.googlegroups.com...
>
>
>
>
>
> > Sirtris Reports Promising Diabetes Study
> > By KEITH J. WINSTEIN
> > January 8, 2008; Page D3
>
> > Sirtris Pharmaceuticals Inc. said its formulation of resveratrol, a
> > substance found in red wine, helped diabetics lower their blood sugar
> > in an early-stage clinical trial.
>
> > Sirtris, Cambridge, Mass., is working on commercializing resveratrol
> > and related drugs to fight a number of diseases. Advocates suspect
> > resveratrol may also increase life span, though that hasn't yet been
> > shown.
>
> > Sirtris released results yesterday from an early-stage study involving
> > 98 diabetics at an investor conference sponsored by J.P. Morgan Chase
> > & Co. in San Francisco. It is the first study to show beneficial
> > effects in humans from resveratrol. Previous studies had focused on
> > mice and rats.
>
> > "We chose diabetes because it's a big market, but the biology says the
> > drug could work on any number of diseases," said David Sinclair, a
> > professor at Harvard Medical School and co-founder of Sirtris. The
> > company has said 2012 is the earliest it could get to the market with
> > a diabetes drug, which would happen only if further phases of clinical
> > testing in much larger groups of patients are successful.
>
> > In the so-called Phase-1b study, Sirtris gave daily doses of
> > resveratrol to 67 diabetics who weren't on other treatment. It gave
> > placebos to 31 others. The study took place in India.
>
> > After 28 days, those taking resveratrol had improved their scores on
> > an oral glucose-tolerance test, which measures the body's ability to
> > break down and use sugar, a fundamental problem for diabetics. Those
> > taking the placebo didn't show an improvement.
>
> > Resveratrol also seemed to lower base-line levels of glucose in the
> > blood, though that result wasn't statistically significant. None of
> > the patients reported a significant side effect, the company said.
>
> > Write to Keith J. Winstein at keith.winst...[at]wsj.com
>
> FYI: Mercola sells a supplement called Radical Fruits that is supposed to
> have some resveratrol in it. *It is an alternative to red wine, for those of
> us that don't drink.
>
> I have no connection to Mercola, except as a customer. *I pick and chose
> from his ideas. *He has some ideas that are great, and he has some ideasI
> can't accept.- Hide quoted text -
>
> - Show quoted text -

#5 01-09-2008, 08:49 AM

Cubit wrote:
- quote -

> Andrew, in the Holy Spirit, boldly wrote:
>
> > Wiser to address the cause, which is VAT, which arises from
> > overeating:
> >
> > http://HeartMDPhD.com/BeHealthy
>
> The VAT...

Yes...

May dear neighbors, friends, and brethren have a blessedly wonderful
2008th year since the birth of our LORD Jesus Christ as the Son of
Man ...

.... by being hungrier:

http://TruthRUS.org/KnowingGOD

Hunger is wonderful :-)

It's how we know what GOD wants, which is what is good.

Yes, hunger is our knowledge of good versus evil that Adam and Eve
paid for with their and our immortal lives.

Those who suffer from the powerful delusion predicted by the prophecy
of 2 Thessalonians 2:9-11 would deny this and perish however:

http://HeartMDPhD.com/Convicts/CrazyOne

http://HeartMDPhD.com/Convicts/CrazyTwo

http://HeartMDPhD.com/Convicts/CrazyThree

Be hungry... be healthy... be hungrier... be blessed:

http://HeartMDPhD.com/HolySpirit/BeBlessed

"Blessed are you who hunger NOW...

.... for you will be satisfied." -- LORD Jesus Christ (Luke 6:21)

Amen.

Prayerfully in the infinite power and might of the Holy Spirit,

Andrew <> <
--
Andrew B. Chung, MD/PhD
Lawful steward of http://EmoryCardiology.com
Bondservant to the KING of kings and LORD of lords.

#4 01-09-2008, 01:33 AM

Cubit wrote:
- quote -

> "Marilyn Mann" <mannm[at]comcast.net> wrote in message
> news:569e9ad6-685d-4fef-a7e7-70efbbc5f959[at]v4g2000hsf.googlegroups.com...
> > Sirtris Reports Promising Diabetes Study
> > By KEITH J. WINSTEIN
> > January 8, 2008; Page D3
> >
> > Sirtris Pharmaceuticals Inc. said its formulation of resveratrol, a
> > substance found in red wine, helped diabetics lower their blood sugar
> > in an early-stage clinical trial.
> >
> > Sirtris, Cambridge, Mass., is working on commercializing resveratrol
> > and related drugs to fight a number of diseases. Advocates suspect
> > resveratrol may also increase life span, though that hasn't yet been
> > shown.
> >
> > Sirtris released results yesterday from an early-stage study involving
> > 98 diabetics at an investor conference sponsored by J.P. Morgan Chase
> > & Co. in San Francisco. It is the first study to show beneficial
> > effects in humans from resveratrol. Previous studies had focused on
> > mice and rats.
> >
> > "We chose diabetes because it's a big market, but the biology says the
> > drug could work on any number of diseases," said David Sinclair, a
> > professor at Harvard Medical School and co-founder of Sirtris. The
> > company has said 2012 is the earliest it could get to the market with
> > a diabetes drug, which would happen only if further phases of clinical
> > testing in much larger groups of patients are successful.
> >
> > In the so-called Phase-1b study, Sirtris gave daily doses of
> > resveratrol to 67 diabetics who weren't on other treatment. It gave
> > placebos to 31 others. The study took place in India.
> >
> > After 28 days, those taking resveratrol had improved their scores on
> > an oral glucose-tolerance test, which measures the body's ability to
> > break down and use sugar, a fundamental problem for diabetics. Those
> > taking the placebo didn't show an improvement.
> >
> > Resveratrol also seemed to lower base-line levels of glucose in the
> > blood, though that result wasn't statistically significant. None of
> > the patients reported a significant side effect, the company said.
> >
> > Write to Keith J. Winstein at keith.winstein[at]wsj.com
> >
>
> FYI: Mercola sells a supplement called Radical Fruits that is supposed to
> have some resveratrol in it. It is an alternative to red wine, for those of
> us that don't drink.
>
> I have no connection to Mercola, except as a customer. I pick and chose
> from his ideas. He has some ideas that are great, and he has some ideas I
> can't accept.
>
>

I don't drink either so in my research I found some encapsulated red
wine concentrate (powder) that is standardized to 20% polyphenols. I've
been taking this for about two years.

The last place I purchased some was here:
Nature's Plus Red Wine - 500 mg/capsule, 60 capsules.
http://www.vitacost.com/Natures-Plus-Red-Wine

--

Pramesh Rutaji

p297tongue6221[at]newsguy.com - remove tongue to reply

#3 01-09-2008, 01:28 AM

"Andrew B. Chung, MD/PhD" <heartdoc23[at]emorycardiology.com> wrote in message
news:bb291066-f909-4c12-834d-1ae666778a2d[at]e25g2000prg.googlegroups.com...
- quote -

> Wiser to address the cause, which is VAT, which arises from
> overeating:

The VAT tax arises from politics. I see it as an unfair tax to those living
on fixed incomes and entitlement programs.

#2 01-09-2008, 01:26 AM

"Marilyn Mann" <mannm[at]comcast.net> wrote in message
news:569e9ad6-685d-4fef-a7e7-70efbbc5f959[at]v4g2000hsf.googlegroups.com...
- quote -

> Sirtris Reports Promising Diabetes Study
> By KEITH J. WINSTEIN
> January 8, 2008; Page D3
>
> Sirtris Pharmaceuticals Inc. said its formulation of resveratrol, a
> substance found in red wine, helped diabetics lower their blood sugar
> in an early-stage clinical trial.
>
> Sirtris, Cambridge, Mass., is working on commercializing resveratrol
> and related drugs to fight a number of diseases. Advocates suspect
> resveratrol may also increase life span, though that hasn't yet been
> shown.
>
> Sirtris released results yesterday from an early-stage study involving
> 98 diabetics at an investor conference sponsored by J.P. Morgan Chase
> & Co. in San Francisco. It is the first study to show beneficial
> effects in humans from resveratrol. Previous studies had focused on
> mice and rats.
>
> "We chose diabetes because it's a big market, but the biology says the
> drug could work on any number of diseases," said David Sinclair, a
> professor at Harvard Medical School and co-founder of Sirtris. The
> company has said 2012 is the earliest it could get to the market with
> a diabetes drug, which would happen only if further phases of clinical
> testing in much larger groups of patients are successful.
>
> In the so-called Phase-1b study, Sirtris gave daily doses of
> resveratrol to 67 diabetics who weren't on other treatment. It gave
> placebos to 31 others. The study took place in India.
>
> After 28 days, those taking resveratrol had improved their scores on
> an oral glucose-tolerance test, which measures the body's ability to
> break down and use sugar, a fundamental problem for diabetics. Those
> taking the placebo didn't show an improvement.
>
> Resveratrol also seemed to lower base-line levels of glucose in the
> blood, though that result wasn't statistically significant. None of
> the patients reported a significant side effect, the company said.
>
> Write to Keith J. Winstein at keith.winstein[at]wsj.com
>

FYI: Mercola sells a supplement called Radical Fruits that is supposed to
have some resveratrol in it. It is an alternative to red wine, for those of
us that don't drink.

I have no connection to Mercola, except as a customer. I pick and chose
from his ideas. He has some ideas that are great, and he has some ideas I
can't accept.

#1 01-08-2008, 04:01 PM

On Jan 8, 3:55 am, Marilyn Mann <ma...[at]comcast.net> wrote: Resveratrol
<<

http://www.resveratrolnews.com/page77.htm

Researchers Show Resveratrol
Works In The Brain By Metal Chelating Effects

Researchers now convincingly show that, via its iron-chelating
effects, resveratrol is able to cross barriers that protect the brain
from entry of toxins (blood/brain barrier) and reduce oxidation
(spoilage) of fats and increase the activity of protective antioxidant
enzymes in the brain of healthy rodents. The research has application
for age-related brain disorders such as Alzheimer's and Parkinson's
disease.

Resveratrol decreased malondialdehyde (an end product of oxidation of
fats) in brain tissues by -300%. Doses ranging (in human equivalents)
from 87.5 to 875 milligrams were effective in this regard. Higher
doses were not more effective.

Resveratrol also significantly increased the activity of antioxidant
enzymes superoxide dismutase, catalase and peroxidase by 160%, 270%
and 210% (see above chart). The forms of most of these protective
enzymes were iron-controlling proteins, confirming that resveratrol's
primary action is via its ability to control metallic metals. Loose
(free) iron causes tissue damage in all forms of age-related brain
disease. While a relatively high dose of resveratrol was shown to be
most effective (875 milligrams human equivalent dose), this was only a
7-day study. It is expected that a life-long accumulation of iron in
brain tissues will require a high loading dose and a lower maintenance
dose. The current fad of ultra-high dose resveratrol supplementation
may be beneficial initially, but lead to anemias over longer term
use. -Resveratrol News April 2007

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Articles, papers, arguments & opinions, thoughts, all welcome.
Email to: admin[at]resveratrolnews.com
Our FORUM operates 24/7 ... LIVE.

- quote -

> Sirtris Reports Promising Diabetes Study
> By KEITH J. WINSTEIN
> January 8, 2008; Page D3
>
> Sirtris Pharmaceuticals Inc. said its formulation of resveratrol, a
> substance found in red wine, helped diabetics lower their blood sugar
> in an early-stage clinical trial.
>
> Sirtris, Cambridge, Mass., is working on commercializing resveratrol
> and related drugs to fight a number of diseases. Advocates suspect
> resveratrol may also increase life span, though that hasn't yet been
> shown.
>
> Sirtris released results yesterday from an early-stage study involving
> 98 diabetics at an investor conference sponsored by J.P. Morgan Chase
> & Co. in San Francisco. It is the first study to show beneficial
> effects in humans from resveratrol. Previous studies had focused on
> mice and rats.
>
> "We chose diabetes because it's a big market, but the biology says the
> drug could work on any number of diseases," said David Sinclair, a
> professor at Harvard Medical School and co-founder of Sirtris. The
> company has said 2012 is the earliest it could get to the market with
> a diabetes drug, which would happen only if further phases of clinical
> testing in much larger groups of patients are successful.
>
> In the so-called Phase-1b study, Sirtris gave daily doses of
> resveratrol to 67 diabetics who weren't on other treatment. It gave
> placebos to 31 others. The study took place in India.
>
> After 28 days, those taking resveratrol had improved their scores on
> an oral glucose-tolerance test, which measures the body's ability to
> break down and use sugar, a fundamental problem for diabetics. Those
> taking the placebo didn't show an improvement.
>
> Resveratrol also seemed to lower base-line levels of glucose in the
> blood, though that result wasn't statistically significant. None of
> the patients reported a significant side effect, the company said.
>
> Write to Keith J. Winstein at keith.winst...[at]wsj.com

01-08-2008, 12:37 PM

Wiser to address the cause, which is VAT, which arises from
overeating:

http://HeartMDPhD.com/BeHealthy

friend Marilyn Mann wrote:
- quote -

> Sirtris Reports Promising Diabetes Study
> By KEITH J. WINSTEIN
> January 8, 2008; Page D3
>
> Sirtris Pharmaceuticals Inc. said its formulation of resveratrol, a
> substance found in red wine, helped diabetics lower their blood sugar
> in an early-stage clinical trial.
>
> Sirtris, Cambridge, Mass., is working on commercializing resveratrol
> and related drugs to fight a number of diseases. Advocates suspect
> resveratrol may also increase life span, though that hasn't yet been
> shown.
>
> Sirtris released results yesterday from an early-stage study involving
> 98 diabetics at an investor conference sponsored by J.P. Morgan Chase
> & Co. in San Francisco. It is the first study to show beneficial
> effects in humans from resveratrol. Previous studies had focused on
> mice and rats.
>
> "We chose diabetes because it's a big market, but the biology says the
> drug could work on any number of diseases," said David Sinclair, a
> professor at Harvard Medical School and co-founder of Sirtris. The
> company has said 2012 is the earliest it could get to the market with
> a diabetes drug, which would happen only if further phases of clinical
> testing in much larger groups of patients are successful.
>
> In the so-called Phase-1b study, Sirtris gave daily doses of
> resveratrol to 67 diabetics who weren't on other treatment. It gave
> placebos to 31 others. The study took place in India.
>
> After 28 days, those taking resveratrol had improved their scores on
> an oral glucose-tolerance test, which measures the body's ability to
> break down and use sugar, a fundamental problem for diabetics. Those
> taking the placebo didn't show an improvement.
>
> Resveratrol also seemed to lower base-line levels of glucose in the
> blood, though that result wasn't statistically significant. None of
> the patients reported a significant side effect, the company said.
>
> Write to Keith J. Winstein at keith.winstein[at]wsj.com

#-1 01-08-2008, 10:55 AM

Sirtris Reports Promising Diabetes Study
By KEITH J. WINSTEIN
January 8, 2008; Page D3

Sirtris Pharmaceuticals Inc. said its formulation of resveratrol, a
substance found in red wine, helped diabetics lower their blood sugar
in an early-stage clinical trial.

Sirtris, Cambridge, Mass., is working on commercializing resveratrol
and related drugs to fight a number of diseases. Advocates suspect
resveratrol may also increase life span, though that hasn't yet been
shown.

Sirtris released results yesterday from an early-stage study involving
98 diabetics at an investor conference sponsored by J.P. Morgan Chase
& Co. in San Francisco. It is the first study to show beneficial
effects in humans from resveratrol. Previous studies had focused on
mice and rats.

"We chose diabetes because it's a big market, but the biology says the
drug could work on any number of diseases," said David Sinclair, a
professor at Harvard Medical School and co-founder of Sirtris. The
company has said 2012 is the earliest it could get to the market with
a diabetes drug, which would happen only if further phases of clinical
testing in much larger groups of patients are successful.

In the so-called Phase-1b study, Sirtris gave daily doses of
resveratrol to 67 diabetics who weren't on other treatment. It gave
placebos to 31 others. The study took place in India.

After 28 days, those taking resveratrol had improved their scores on
an oral glucose-tolerance test, which measures the body's ability to
break down and use sugar, a fundamental problem for diabetics. Those
taking the placebo didn't show an improvement.

Resveratrol also seemed to lower base-line levels of glucose in the
blood, though that result wasn't statistically significant. None of
the patients reported a significant side effect, the company said.

Write to Keith J. Winstein at keith.winstein[at]wsj.com

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