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#108
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| Andrew B. Chung, MD/PhD wrote: - quote - > Marshall Price wrote:
Huh?> > Andrew, in the Holy Spirit, wrote in part: > > > > > By GOD's design, there is one optimal amount for every adult as > > > denoted by the Hebrew word "omer" (Exodus 16:16). > > Why not save us the trouble of looking it up? > > "Each one is to gather as much as he needs. Take an omer for each > person you have in your tent." -- LORD Almighty GOD (Exodus 16:16) > > 16 + 16 = 32 > > Reminding us that the one optimal amount is 32 ounces. You take the numbers from the chapter and verse? But those aren't in the original. Then you add them together? Why? Why "ounces"? "Optimal amount" of what? Manna? Per day? An omer is a tenth of an ephah, which is about a bushel, which is about 32 quarts, so an omer (as a measure of grain) is about 3.2 quarts. That's "an optimal amount" for a day? Why take something God said to the Israelites gathering manna in the desert (if I recall correctly) as his "design" for "every adult"? And where are you getting manna, anyway? -- Marshall Price of Miami Known to Yahoo as d021317c |
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#107
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| In article <-5mdnfjWNLwkbbLVnZ2dnUVZ_tHinZ2d[at]earthlink.com> , Marshall Price <d021317c[at]yahoo.com> wrote: - quote - > jay wrote: > > > > What supplements provide relief from polyneuropathy? > > > Nobody seems to have mentioned the most obvious one, thiamine! > > > > My multi-vitamin says one tablet has 75mg of Thiamine HCl (5000%). Is > > this too much? > > It sounds like too much to me, but many people take that much, or > more. The multi-vitamin-mineral tablets I take afford about one DV > (that is, 100%) for each vitamin and mineral, except for the major > minerals. (For thiamine, that means 1.5mg.) > > But I also take a few vitamins "on the side" for specific purposes, > and I expect to get most of my nutrients from food, not to mention the > zillions of honored guest symbiotes in my digestive tract. I'd be lost > without them. ;-) It's not too much. I take 540mg Thiamine per day. |
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#106
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| On May 18, 1:31 am, Marshall Price <d0213...[at]yahoo.com> wrote: - quote - > Andrew B. Chung, MD/PhD wrote:
Chung has been told many times that scholars agree that an omer is a> > > By GOD's design, there is one optimal amount for every adult as > > denoted by the Hebrew word "omer" (Exodus 16:16). > > Why not save us the trouble of looking it up? > > -- > Marshall Price of Miami > Known to Yahoo as d021317c biblical measure of volume equivalent to approximately 2 liters or quarts. Yet he is fixated on the fact that the verse mentioning an omer as being the right amount of food for the Israelites wandering in the desert is Exodus 16:16. He therefore twists this to be numerology "proof" that an omer is 2 pounds or 32 ounces. Chung initially fixated on the 2 pounds per person per day diet when he saw some IMAX film about Everest climbers and mistakenly came away with the idea that those climbers ate only 2 pounds of food per day. As his mental illness progressed and he became more fixated on quasi- Christianity, this 2 pounds a day morphed from being inspired by the IMAX Everest film into being inspired by Chung's lone ranger, idiosyncratic and mistaken interpretation of the biblical measure of volume, an omer. Chung is a disgraced ex-cardiologist who lost his first post- cardiology fellowship job in Ocala, Florida in about 3 months and has not worked since. He is a pathological, regressed narcissist and a known Usenet k00k and a pathological liar. Respond to his posts for amusement value only. Nothing that he says is evidence-based. |
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#105
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| jay wrote: - quote - > > > What supplements provide relief from polyneuropathy?
It sounds like too much to me, but many people take that much, or> > Nobody seems to have mentioned the most obvious one, thiamine! > > My multi-vitamin says one tablet has 75mg of Thiamine HCl (5000%). Is > this too much? more. The multi-vitamin-mineral tablets I take afford about one DV (that is, 100%) for each vitamin and mineral, except for the major minerals. (For thiamine, that means 1.5mg.) But I also take a few vitamins "on the side" for specific purposes, and I expect to get most of my nutrients from food, not to mention the zillions of honored guest symbiotes in my digestive tract. I'd be lost without them. ;-) -- Marshall Price of Miami Known to Yahoo as d021317c |
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#104
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| Marshall Price wrote: - quote - > Andrew, in the Holy Spirit, wrote in part:
"Each one is to gather as much as he needs. Take an omer for each> > > By GOD's design, there is one optimal amount for every adult as > > denoted by the Hebrew word "omer" (Exodus 16:16). > > Why not save us the trouble of looking it up? person you have in your tent." -- LORD Almighty GOD (Exodus 16:16) 16 + 16 = 32 Reminding us that the one optimal amount is 32 ounces. Be hungry... be healthy... be hungrier... be euglycemic... Prayerfully in the awesome name of LORD Jesus Christ, Andrew <> < -- http://groups.google.com/group/sci.m...8812d72ab4e17? |
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#103
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| Marshall Price wrote: - quote - > Andrew, in the Holy Spirit, boldly wrote: http://groups.google.com/group/sci.m...e435e3ec529db?> > friend jay wrote: > > > > Be hungry... be healthy... be hungrier... be healthier... > > > Good advice. I try to fast on Sundays. > > > > > > The formation of peripheral myelin protein 22 aggregates is hindered > > > by the enhancement of autophagy and expression of cytoplasmic > > > chaperones. > > > > > > The accumulation of misfolded proteins is associated with various > > > neurodegenerative conditions. Peripheral myelin protein 22 (PMP22) is > > > a hereditary neuropathy-linked, short-lived molecule that forms > > > aggresomes when the proteasome is inhibited or the protein is mutated. > > > We previously showed that the removal of pre-existing PMP22 aggregates > > > is assisted by autophagy. Here we examined whether the accumulation of > > > such aggregates could be suppressed by experimental induction of > > > autophagy and/or chaperones. Enhancement of autophagy during > > > proteasome inhibition hinders protein aggregate formation and > > > correlates with a reduction in accumulated proteasome substrates. > > > Conversely, simultaneous inhibition of autophagy and the proteasome > > > augments the formation of aggregates. An increase of heat shock > > > protein levels by geldanamycin treatment or heat shock preconditioning > > > similarly hampers aggresome formation. The beneficial effects of > > > autophagy and chaperones in preventing the accumulation of misfolded > > > PMP22 are additive and provide a potential avenue for therapeutic > > > approaches in hereditary neuropathies linked to PMP22 mutations. PMID: > > > 17174099 > > > > Fasting can result in hyperketonemia, which suppresses hunger. > > > > It is only when we are hungrier, that our bodies "burn" away the VAT > > (black fat): > > > > http://groups.google.com/group/sci.m...8812d72ab4e17? > > Those links don't mention "VAT" or "black." Be hungry... be healthy... be hungrier... be euglycemic... Prayerfully in the awesome name of LORD Jesus Christ, Andrew <> < -- http://groups.google.com/group/sci.m...8812d72ab4e17? |
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#102
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| Andrew B. Chung, MD/PhD wrote: - quote - > By GOD's design, there is one optimal amount for every adult as
Why not save us the trouble of looking it up?> denoted by the Hebrew word "omer" (Exodus 16:16). -- Marshall Price of Miami Known to Yahoo as d021317c |
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#101
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| timothytn[at]my-deja.com wrote: - quote - > Here is the result of small clinical trials in humans in Germany as of
Taking large amounts of B6 without extra B2 is a no-no.> 1999. There may be more positive evidence since then. High pyridoxine > supplementation usually in excess of 600 mg./day has resulted in > neuropathy in a small number of people. They were taking it for carpal > tunnel syndrome. They were also taking it w/o other B vitamins and the > condition was reversible. Personally I have taken 1000 mg/d for > extended periods w/o side effects. It's probably best to steer clear > of supplementation IMHO. -- Marshall Price of Miami Known to Yahoo as d021317c |
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#100
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| Andrew B. Chung, MD/PhD wrote: - quote - > friend jay wrote:
Those links don't mention "VAT" or "black."> > > Be hungry... be healthy... be hungrier... be healthier... > > Good advice. I try to fast on Sundays. > > > > The formation of peripheral myelin protein 22 aggregates is hindered > > by the enhancement of autophagy and expression of cytoplasmic > > chaperones. > > > > The accumulation of misfolded proteins is associated with various > > neurodegenerative conditions. Peripheral myelin protein 22 (PMP22) is > > a hereditary neuropathy-linked, short-lived molecule that forms > > aggresomes when the proteasome is inhibited or the protein is mutated. > > We previously showed that the removal of pre-existing PMP22 aggregates > > is assisted by autophagy. Here we examined whether the accumulation of > > such aggregates could be suppressed by experimental induction of > > autophagy and/or chaperones. Enhancement of autophagy during > > proteasome inhibition hinders protein aggregate formation and > > correlates with a reduction in accumulated proteasome substrates. > > Conversely, simultaneous inhibition of autophagy and the proteasome > > augments the formation of aggregates. An increase of heat shock > > protein levels by geldanamycin treatment or heat shock preconditioning > > similarly hampers aggresome formation. The beneficial effects of > > autophagy and chaperones in preventing the accumulation of misfolded > > PMP22 are additive and provide a potential avenue for therapeutic > > approaches in hereditary neuropathies linked to PMP22 mutations. PMID: > > 17174099 > > Fasting can result in hyperketonemia, which suppresses hunger. > > It is only when we are hungrier, that our bodies "burn" away the VAT > (black fat): > > http://groups.google.com/group/sci.m...8812d72ab4e17? > > Prayerfully in the awesome name of LORD Jesus Christ, > > Andrew <> < > -- > http://groups.google.com/group/sci.m...50caf5f7c3989? Also, are you aware of the fact that when "lord" is written in upper case, that signals that it is being used as a substitute for the tetragrammaton? "LORD Jesus Christ" is entirely different from "Lord Jesus Christ," and it seems to imply that the author opposes the doctrine of the trinity. "KING," on the other hand, means nothing, except that the author enjoys flouting typographical conventions. -- Marshall Price of Miami Known to Yahoo as d021317c |
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#99
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| Marshall Price wrote: - quote - > Andrew, in the Holy Spirit, boldly wrote:
Pro-Inflammatory AdipoCytokines> > jay wrote: > > > What supplements provide relief from polyneuropathy? Would the > > > following be the most important? Already doing paleo-type diet, > > > moderate exercise and multi-vitamins. > > > > > > Benfotiamine > > > Vitamin B6 (P-5-P) > > > R-Lipoic Acid > > > NAC > > > Acetyl-L-Carnitine > > > > In our collective clinical experience, no supplement(s) can overcome > > the deleterious effect that PIACs from VAT (black fat) has on the > > fragile efferent fibers of sensory neurons thereby causing the > > peripheral neuropathy. > > What are PIACs? Be hungry... be healthy... be hungrier... be euglycemic... Prayerfully in the awesome name of LORD Jesus Christ, Andrew <> < -- http://groups.google.com/group/sci.m...8812d72ab4e17? |
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#98
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| Andrew B. Chung, MD/PhD wrote: - quote - > jay wrote:
What are PIACs?> > What supplements provide relief from polyneuropathy? Would the > > following be the most important? Already doing paleo-type diet, > > moderate exercise and multi-vitamins. > > > > Benfotiamine > > Vitamin B6 (P-5-P) > > R-Lipoic Acid > > NAC > > Acetyl-L-Carnitine > > In our collective clinical experience, no supplement(s) can overcome > the deleterious effect that PIACs from VAT (black fat) has on the > fragile efferent fibers of sensory neurons thereby causing the > peripheral neuropathy. -- Marshall Price of Miami Known to Yahoo as d021317c |
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#97
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| Tiger_Lily wrote: - quote - > jay wrote:
That burning-foot problem might be related to circulatory, not> > > take a look at ..... www.diabetic-talk.org/dpn.htm > > Thanks. They recommends a cocktail of slow-released Lipoic Acid, EPO > > and Vitamin C. Is the reason why EPO helps neuropathy well > > established? Is the below related? > > i don't know the details, i didn't write the article, nor do the > research for it > > i DO KNOW 6 or 7 diabetics who no longer have the tingling/burning/socks > under the toes feelings that they used to have > > good bg control is imperative as well.... > neurological, trouble. I had that symptom when my cholesterol was high. Adele Davis recommended pantothenic acid (vitamin B5) for burning feet, which didn't help me. But pantethine, which is closely related to it, is among the three B vitamins, including niacin (vitamin B3) and pyridoxine (vitamin B6), which definitely do lower LDL cholesterol. (I don't know much about pantethine, but pantothenic acid works the same way, costs much less, and is almost as effective.) And I ate two to six cups of cooked oat bran every day, which also has been proven to work. The peripheral neuropathy I cleared up by taking thiamine (vitamin B1) was different. It showed up as a small area of numbness on the medial aspect of my right big toe -- and it went away fast, probably because I reacted quickly. In any case, losing one third of my weight by fasting seems to have solved both problems permanently for me -- and not only did it cost nothing, but it actually saved me my food budget for six weeks! -- Marshall Price of Miami Known to Yahoo as d021317c |
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#96
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| On May 16, 4:39*pm, jay <jaym1...[at]hotmail.com> wrote: - quote - > > > What supplements provide relief from polyneuropathy?
Naw, there is research comparing benforiamine and thiamine> > > *Nobody seems to have mentioned the most obvious one, thiamine! > > My multi-vitamin says one tablet has 75mg of Thiamine HCl (5000%). Is > this too much? and the doses needed of thiamine were 10 to 15 times that for a modest competative response. The benfotiamine was more effective at lower dose. As I recall the therapeutic dose of benfotiamine was 300 milligrams. Huge numbers take 50 to 100 mg of thiamine daily and people aren't dying in the streets. With all B-vitamins one is well advised to take not one vitamin but all the B-vitamins and even some magnesium during the day. A high level one can increase the need for higher levels of some of the others. I recently say article on this point having to do with folic acid and cobalamin. And I've read this comment about thiamine and the other Bs, and B-6 and magnesium as examples. This is also true with the fat soluble vitamins. If one takes E then one should take K. If one takes D then one should take K. If one takes A then one should likely take D. If one take A one should also take E. If one take alpha tocopherol then one should take gamma tocopherol and the others as well. And I suppose a mixture of K1 and K2 will likely have some merits. And most multi vitamins just don't cut especially the most massively marketed ones i.e. One a Day, Centrum and their ilk. |
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#95
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| - quote - > > What supplements provide relief from polyneuropathy?
My multi-vitamin says one tablet has 75mg of Thiamine HCl (5000%). Is> > *Nobody seems to have mentioned the most obvious one, thiamine! this too much? |
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#94
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| On Fri, 16 May 2008 17:40:01 -0400, Marshall Price <d021317c[at]yahoo.com> wrote: - quote - > jay wrote:
Benfotiamine is a better source than thiamine, it's got more> > What supplements provide relief from polyneuropathy? Would the > > following be the most important? Already doing paleo-type diet, > > moderate exercise and multi-vitamins. > > > > Benfotiamine > > Vitamin B6 (P-5-P) > > R-Lipoic Acid > > NAC > > Acetyl-L-Carnitine > > Nobody seems to have mentioned the most obvious one, thiamine! absorption sites. Nicky. T2 dx 05/04 + underactive thyroid D&E, 100ug thyroxine Last A1c 5.6% BMI 25 |
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#93
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| timoth...[at]my-deja.com wrote: - quote - >
A GI tract including its bacterial flora that is processing an optimal> Here is the result of small clinical trials in humans in Germany as of > 1999. There may be more positive evidence since then. High pyridoxine > supplementation usually in excess of 600 mg./day has resulted in > neuropathy in a small number of people. They were taking it for carpal > tunnel syndrome. They were also taking it w/o other B vitamins and the > condition was reversible. Personally I have taken 1000 mg/d for > extended periods w/o side effects. It's probably best to steer clear > of supplementation IMHO. amount of food each day is one that is capable, with GOD's blessing, of extracting and supplying the required nutrients (macro, micro, and trace) in a precisely regulated fashion to meet the specific highly variable requirements of the body. By GOD's design, there is one optimal amount for every adult as denoted by the Hebrew word "omer" (Exodus 16:16). Have been eating HIS optimal amount since 1997 so that I can personally testify that GOD is absolutely right in HIS design. Laus Deo ! ! ! Be hungry... be healthy... be hungrier... be euglycemic... Prayerfully in the awesome name of LORD Jesus Christ, Andrew <> < -- http://groups.google.com/group/sci.m...8812d72ab4e17? |
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#92
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| jay wrote: - quote - > What supplements provide relief from polyneuropathy? Would the
Nobody seems to have mentioned the most obvious one, thiamine!> following be the most important? Already doing paleo-type diet, > moderate exercise and multi-vitamins. > > Benfotiamine > Vitamin B6 (P-5-P) > R-Lipoic Acid > NAC > Acetyl-L-Carnitine -- Marshall Price of Miami Known to Yahoo as d021317c |
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#91
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| Here is the result of small clinical trials in humans in Germany as of 1999. There may be more positive evidence since then. High pyridoxine supplementation usually in excess of 600 mg./day has resulted in neuropathy in a small number of people. They were taking it for carpal tunnel syndrome. They were also taking it w/o other B vitamins and the condition was reversible. Personally I have taken 1000 mg/d for extended periods w/o side effects. It's probably best to steer clear of supplementation IMHO. Exp Clin Endocrinol Diabetes. 1999;107(7):421-30.Links Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials.Ziegler D, Reljanovic M, Mehnert H, Gries FA. Diabetes-Forschungsinstitut an der Heinrich-Heine-Universität, Düsseldorf, Germany. dan.ziegler[at]dfi.uni-duesseldorf.de Diabetic neuropathy represents a major health problem, as it is responsible for substantial morbidity, increased mortality, and impaired quality of life. Near-normoglycaemia is now generally accepted as the primary approach to prevention of diabetic neuropathy, but is not achievable in a considerable number of patients. In the past two decades several medical treatments that exert their effects despite hyperglycaemia have been derived from the experimental pathogenetic concepts of diabetic neuropathy. Such compounds have been designed to improve or slow the progression of the neuropathic process and are being evaluated in clinical trials, but with the exception of alpha-lipoic acid (thioctic acid) which is available in Germany, none of these drugs is currently available in clinical practice. Here we review the current evidence from the clinical trials that assessed the therapeutic efficacy and safety of thioctic acid in diabetic polyneuropathy. Thus far, 15 clinical trials have been completed using different study designs, durations of treatment, doses, sample sizes, and patient populations. Within this variety of clinical trials, those with beneficial effects of thioctic acid on either neuropathic symptoms and deficits due to polyneuropathy or reduced heart rate variability resulting from cardiac autonomic neuropathy used doses of at least 600 mg per day. The following conclusions can be drawn from the recent controlled clinical trials. 1.) Short-term treatment for 3 weeks using 600 mg of thioctic acid i.v. per day appears to reduce the chief symptoms of diabetic polyneuropathy. A 3-week pilot study of 1800 mg per day given orally indicates that the therapeutic effect may be independent of the route of administration, but this needs to be confirmed in a larger sample size. 2.) The effect on symptoms is accompanied by an improvement of neuropathic deficits. 3.) Oral treatment for 4-7 months tends to reduce neuropathic deficits and improves cardiac autonomic neuropathy. 4.) Preliminary data over 2 years indicate possible long-term improvement in motor and sensory nerve conduction in the lower limbs. 5.) Clinical and postmarketing surveillance studies have revealed a highly favourable safety profile of the drug. Based on these findings, a pivotal long-term multicenter trial of oral treatment with thioctic acid (NATHAN I Study) is being conducted in North America and Europe aimed at slowing the progression of diabetic polyneuropathy using a clinically meaningful and reliable primary outcome measure that combines clinical and neurophysiological assessment. PMID: 10595592 [PubMed - indexed for MEDLINE] |
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#90
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| friend jay wrote: - quote - >
Fasting can result in hyperketonemia, which suppresses hunger.> > Be hungry... be healthy... be hungrier... be healthier... > > Good advice. I try to fast on Sundays. > > The formation of peripheral myelin protein 22 aggregates is hindered > by the enhancement of autophagy and expression of cytoplasmic > chaperones. > > The accumulation of misfolded proteins is associated with various > neurodegenerative conditions. Peripheral myelin protein 22 (PMP22) is > a hereditary neuropathy-linked, short-lived molecule that forms > aggresomes when the proteasome is inhibited or the protein is mutated. > We previously showed that the removal of pre-existing PMP22 aggregates > is assisted by autophagy. Here we examined whether the accumulation of > such aggregates could be suppressed by experimental induction of > autophagy and/or chaperones. Enhancement of autophagy during > proteasome inhibition hinders protein aggregate formation and > correlates with a reduction in accumulated proteasome substrates. > Conversely, simultaneous inhibition of autophagy and the proteasome > augments the formation of aggregates. An increase of heat shock > protein levels by geldanamycin treatment or heat shock preconditioning > similarly hampers aggresome formation. The beneficial effects of > autophagy and chaperones in preventing the accumulation of misfolded > PMP22 are additive and provide a potential avenue for therapeutic > approaches in hereditary neuropathies linked to PMP22 mutations. PMID: > 17174099 It is only when we are hungrier, that our bodies "burn" away the VAT (black fat): http://groups.google.com/group/sci.m...8812d72ab4e17? Prayerfully in the awesome name of LORD Jesus Christ, Andrew <> < -- http://groups.google.com/group/sci.m...50caf5f7c3989? |
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#89
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| - quote - > Be hungry... be healthy... be hungrier... be healthier...
Good advice. I try to fast on Sundays.The formation of peripheral myelin protein 22 aggregates is hindered by the enhancement of autophagy and expression of cytoplasmic chaperones. The accumulation of misfolded proteins is associated with various neurodegenerative conditions. Peripheral myelin protein 22 (PMP22) is a hereditary neuropathy-linked, short-lived molecule that forms aggresomes when the proteasome is inhibited or the protein is mutated. We previously showed that the removal of pre-existing PMP22 aggregates is assisted by autophagy. Here we examined whether the accumulation of such aggregates could be suppressed by experimental induction of autophagy and/or chaperones. Enhancement of autophagy during proteasome inhibition hinders protein aggregate formation and correlates with a reduction in accumulated proteasome substrates. Conversely, simultaneous inhibition of autophagy and the proteasome augments the formation of aggregates. An increase of heat shock protein levels by geldanamycin treatment or heat shock preconditioning similarly hampers aggresome formation. The beneficial effects of autophagy and chaperones in preventing the accumulation of misfolded PMP22 are additive and provide a potential avenue for therapeutic approaches in hereditary neuropathies linked to PMP22 mutations. PMID: 17174099 |
| Tags |
| neuropathy, supplements |
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